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Trifluoromethanesulfonic acid-catalyzed solvent-free bisindolylation of trifluoromethyl ketones
Authors:Yi Wang  Yu Yuan  Chun-Hui Xing  Long Lu
Affiliation:1. College of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu Province 225002, PR China;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, 200032 Shanghai, PR China
Abstract:A trifluoromethanesulfonic acid-catalyzed solvent-free bisindolylation reaction of indoles with alkyl and aryl trifluoromethyl ketones has been developed. The trifluoromethyl-substituted bisindolylalkane derivatives were synthesized in moderate to excellent yields.
Keywords:Bisindolylation   Solvent-free   Trifluoromethyl ketone   Indole   Trifluoromethanesulfonic acid
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