Chemical conjugation of an mRNA cap analogue with a cell-penetrating peptide as a potential membrane permeable translation inhibitor |
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| Authors: | Karolina Piecyk Marzena Jankowska-Anyszka |
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| Affiliation: | Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland |
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| Abstract: | We present a versatile method for chemical conjugation of a dinucleotide cap analogue with a cell-penetrating peptide. The final coupling reaction is between an azide-modified peptide (MPS-N3)—a fragment that is responsible for transport of the conjugate through the cell membrane, with a biologically active compound—and an alkynylated cap structure, using the Cu(I)-catalyzed click reaction. |
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| Keywords: | Cap analogue Cell-penetrating peptides Click chemistry Drug delivery |
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