Domino synthesis of 1,3-diynes from 1,1-dibromoalkenes: a Pd-catalyzed copper-free coupling method |
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| Authors: | Maddali L.N. Rao Priyabrata DasguptaBoddu S. Ramakrishna Venneti N. Murty |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208 016, India |
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| Abstract: | Pd-catalyzed domino synthesis of 1,3-diynes was accomplished using 1,1-dibomoalkenes under copper-free coupling conditions. This domino procedure involves base mediated in situ generation of 1-bromoalkyne and its subsequent coupling to give 1,3-diyne. The optimized copper-free coupling method afforded good to high yields of symmetrical 1,3-diynes in a one-pot operation. |
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| Keywords: | Pd-catalyzed 1,1-Dibromoalkenes Domino Couplings Copper-free 1,3-Diynes |
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