Convenient method for the synthesis of phthalazinones via carbonylation of 2-bromobenzaldehyde using Co2(CO)8 as a CO source |
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| Authors: | A Sivalingam Suresh Poongavanam Baburajan Mansur Ahmed |
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| Institution: | 1. Research Department of Chemistry, Islamiah College, Vaniyambadi 635752, India;2. Syngene International Limited, Bangalore 560099, India |
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| Abstract: | A simple one-pot synthesis of phthalazinones by the condensation and intra-molecular carbonylative cyclization of 2-bromobenzaldehydes with hydrazines is reported. This method utilizes solid Co2(CO)8 as carbonyl source making it readily accessible in small-scale laboratory applications. |
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| Keywords: | Phthalazinone Palladium Carbonylation Aryl halides Co2(CO)8 Hydrazines |
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