Synthesis of a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]pyridine derivative,the 5-aza analog of ramelteon |
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| Authors: | Yasutaka Hoashi Takafumi TakaiTatsuki Koike Osamu Uchikawa |
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| Affiliation: | Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan |
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| Abstract: | The 5-aza analog of ramelteon 3, a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]pyridine derivative, was synthesized by hetero-Diels–Alder reaction and chemoselective Dieckmann condensation. |
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| Keywords: | Ramelteon Cyclopenta[b]furo[3,2-d]pyridine Hetero-Diels&ndash Alder reaction Chemoselective Dieckmann condensation |
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