AB3 building blocks for the synthesis of polyester dendrimers |
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| Authors: | Jean-d’Amour K Twibanire Malcolm P Huestis T Bruce Grindley |
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| Institution: | 1. Department of Chemistry, Dalhousie University, Halifax, NS B3H 4J3, Canada;2. CanAm Bioresearch Inc., Winnipeg, MB R3T 0P4, Canada;3. Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA |
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| Abstract: | Syntheses of several examples of a new type of trivalent building blocks for the preparation of aliphatic polyester dendrimers are presented. Starting from the well-known mono-O-benzylidenepentaerythritol, AB3 type acid dendrons can be obtained in high yield in only two steps. Other triprotected bis-2,2-(hydroxymethyl)-3-hydroxypropanoic acid derivatives with varying protecting groups were also synthesized readily. This type of dendron was used in combination with 2,2′-bis(hydroxymethyl) propanoic acid (bis-HMPA) divalent dendrons to produce low generation mixed polyester dendrimers with increased number of branching points. |
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| Keywords: | Dendrons Polyester dendrimers Mono-O-benzylidenepentaerythritol Tribranched dendrons |
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