An eco-compatible multicomponent strategy for the synthesis of new 2-amino-6-(1H-indol-3-yl)-4-arylpyridine-3,5-dicarbonitriles in aqueous micellar medium promoted by thiamine-hydrochloride |
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| Authors: | Shahin Fatma Divya SinghPreyas Ankit Priya MishraMandavi Singh Jagdamba Singh |
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| Institution: | Department of Chemistry, University of Allahabad, Allahabad 211002, India |
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| Abstract: | A thiamine hydrochloride (VB1) accelerated, one-pot synthesis of 2-amino-6-(1H-indol-3-yl)-4-arylpyridine-3,5-dicarbonitriles was achieved via four-component reaction of 3-cyanoacetyl indole, aromatic aldehydes, ammonium acetate, and malononitrile in aqueous micellar conditions by a Knoevenagel condensation reaction followed by Michael-addition, which upon cyclization and dehydration yielded the corresponding product in excellent proportion. |
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| Keywords: | Thiamine hydrochloride Cyano acetyl indole One-pot CTAB Michael addition |
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