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A practical nickel-catalyzed reductive alkylation of amidophenyl bromides |
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| Authors: | Xuge Liu Zhilin YangYa-Min Li Fan YangLiang Feng Nengzhong WangDebiao Ma Kwen-Jen ChangYuehai Shen |
| Affiliation: | Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China |
| Abstract: | A modified Weix's reductive coupling for alkylation of amidoaryl bromides based on Ni(COD)2 precatalyst and 2,2′-dipyridyl ligand was developed. This reaction is reliable for amidophenyl bromides and gives yields up to 87%, and is potentially useful in the synthesis of amidophenyl-containing molecules. |
| Keywords: | Reductive coupling Nickel Amidophenyl bromide |
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