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An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris |
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| Authors: | Li Zhang Chun-Jiang Zhang Dong-Bo Zhang Juan Wen Xiao-Wei Zhao Ya Li Kun Gao |
| Institution: | 1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China;2. College of Life Science, Lanzhou University, Lanzhou 730000, People’s Republic of China;3. School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, People’s Republic of China |
| Abstract: | A novel alkaloid, 17-nor-excelsinidine (1), possessing an unusual 1-azoniatricyclo 4.3.3.0] undecane moiety was isolated from the twigs and leaves of Alstonia scholaris alongside its biogenetically related strictamine (2). The structure and absolute stereochemistry of compound 1 were rigorously determined by a combination of NMR spectroscopy and X-ray crystallography. The 17-nor-excelsinidine (1) and strictamine (2) showed significant inhibitory activity against herpes simplex virus (HSV) and adenovirus (ADV). |
| Keywords: | Alstonia scholaris Indole alkaloids Anti-adenovirus Anti-HSV |
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