Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks |
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Authors: | Banothu Janardhan Basavoju Srinivas Bavantula Rajitha Crooks Peter A |
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Institution: | 1. Department of Chemistry, National Institute of Technology, Warangal 506 004, A.P., India;2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA |
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Abstract: | 2-Chloro-N-phenylacetamide and N-(benzod]thiazol-2-yl)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound 6c confirmed the structure of all the reaction products. |
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Keywords: | Thiazolo[3 2-a]pyrimidinones 2-Chloro-N-phenylacetamide N-(Benzo[d]thiazol-2-yl)-2-chloroacetamide Single crystal X-ray analysis |
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