Catalyst-free,ethylene glycol promoted one-pot three component synthesis of 3-amino alkylated indoles via Mannich-type reaction |
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Authors: | U Chinna Rajesh Rohit KholiyaV Satya Pavan Diwan S Rawat |
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Institution: | Department of Chemistry, University of Delhi, Delhi 110007, India |
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Abstract: | A highly efficient and sustainable approach for the multi-component synthesis of biologically important 3-amino alkylated indoles has been investigated via Mannich-type reaction under catalyst-free, ethylene glycol as a recyclable promoting medium. The wide applicability of the present method was examined with various substrates viz substituted aldehydes, indoles and secondary amines. This method will be useful for a large scale synthesis of 3-amino alkylated indoles without the use of column chromatography. The present method provides higher environmental compatibility and sustainability factors such as smaller E-factor (0.433) and higher atom-economy (AE = 93.3%). |
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Keywords: | Multi-component reactions E-factor and atom economy Indoles Mannich reaction Catalyst free |
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