Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Rokkodai, Nada-ku, Kobe 657-8501, Japan
Abstract:
Glyceollins are well-known phytoalexins isolated from soybean (Glycine max). An efficient three-step synthesis was developed for the preparation of the key intermediate in Khupse’s glyceollin I synthesis. Claisen rearrangement-cyclization cascade reaction and Suzuki–Miyaura cross coupling were key steps in this method.