Base promoted facile route to functionalized benzo[b][1,8]naphthyridin-2-(1H)-ones from N-benzyl-N-(3-cyanoquinolin-2-yl)acetamides |
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Authors: | Durgesh Nandini Mrityunjaya Asthana Tanu Gupta R.P. Singh Radhey M. Singh |
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Affiliation: | 1. Department of Chemistry, Centre of Advance Studies, Banaras Hindu University, Varanasi, U.P., India;2. Centre for Fire, Explosive & Environment Safety(CFEES), DRDO, Timarpur, Delhi 54, India |
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Abstract: | A facile synthesis of 4-amino-N-benzylbenzo[b][1,8]naphthyridin-2(1H)-ones 3 is described from N-benzyl-N-(3-cyanoquinolin-2-yl)acetamides 2 with t-BuOK in excellent yields in mild conditions. These reactions proceeded at room temperature under aerobic atmosphere in very short period. The cyclization reactions were also extended with N-alkyl amino acetamide analogues affording the products in good yields. |
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Keywords: | Benzo[b][1,8]-naphthyridin-2-one N-Benzyl-N-(3-cyanoquinolin-2-yl)acetamides t-BuOK Acetylation Intramolecular cyclization |
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