Total synthesis of (−)-Englerin A |
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Authors: | Jinghua Zhang Shuyan Zheng Wei Peng Zhengwu Shen |
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Institution: | 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Basilea Pharmaceutical China Ltd, Haimen, Jiangsu 226100, China |
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Abstract: | A novel and efficient total synthesis of Englerin A is reported. The synthesis featured an intramolecular olefin metathesis ring closure reaction and a highly stereoselective oxygen bridge formation induced by an iodonium ion. This strategy can be used for the synthesis of natural products Englerin A and Englerin B and can provide flexibility in the preparation of various 9-substituted analogues of Englerin A for further structure–activity relationship studies. |
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Keywords: | Total synthesis Natural products (&minus )-Englerin A Stereoselective |
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