Fluorous synthesis of mono-dispersed poly(ethylene glycols) |
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Authors: | Yu Li Qi Guo Xuefei Li Hua Zhang Fanghua Yu Weijiang Yu Guiquan Xia Mingyang Fu Zhigang Yang Zhong-Xing Jiang |
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Affiliation: | 1. Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, PR China;2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan 430071, PR China;3. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China |
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Abstract: | Mono-dispersed poly(ethylene glycols) (PEGs) are of great value in the development of biopharmaceuticals. However, tedious synthesis limits the availability of mono-dispersed PEGs. To address this issue, a fluorous synthesis of mono-dispersed PEGs, discretely PEGylated surfactants and 19F magnetic resonance imaging (MRI) agents has been developed. During the synthesis, both fluorous and normal phase silica gel-based solid-phase extractions were successfully employed to simplify the purifications. This synthesis provided an easy access to valuable mono-dispersed PEGs and related molecules for biomedical application on multi-gram scales. |
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Keywords: | Fluorous chemistry Solid-phase extraction Fluorinated surfactant Mono-dispersed PEGs |
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