Ultrasound-assisted addition of alcohols to N-acyliminium ions mediated by In(OTf)3 and synthesis of 1,2,3-triazoles |
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| Authors: | Hé lio A. Stefani,Bakhat Ali,Fernando P. Ferreira |
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| Affiliation: | 1. Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil;2. Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo, SP, Brazil |
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| Abstract: | An easy and mild approach using ultrasound-assisted reaction addition of alcohols to N-acyliminium ion mediated by Lewis acid, In(OTf)3, allowed the synthesis of ether pyrrolidinones; next, the products were converted to 1,2,3-triazoles using click chemistry reaction conditions. The products in both reactions were afforded in moderate to good yields. |
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| Keywords: | N-Acyliminium ion Addition reaction Click chemistry 1,2,3-Triazol Ultrasound |
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