Preparation of dihydrotetrazolo[1,5-a]pyrimidine derivatives from Biginelli 3,4-dihydropyrimidine-2-thiones |
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Authors: | Jamshed Hashim Nuzhat ArshadIjaz Khan Sonia NisarBasharat Ali M. Iqbal Choudhary |
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Affiliation: | H.E.J. Research Institute of Chemistry, ICCBS, University of Karachi, Karachi 75270, Pakistan |
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Abstract: | Dihydropyrimidines (DHPM) with a fused tetrazole ring have been synthesized via a smooth and efficient three-step protocol involving N,S-dimethylated and 2-hydrazinyl-dihydropyrimidine intermediates, respectively. The described protocol is applicable to electron rich and electron poor DHPM precursors as well. The insertion of tetrazole ring in monastrol type dihydropyrimidines makes it interesting for pharmacological investigations. |
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Keywords: | Dihydropyrimidines Tetrazole DHPM scaffold Monastrol Biological activities |
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