Ruthenium catalyzed desymmetrization of diazabicyclic olefins to access heteroaryl substituted cyclopentenes through C–H activation of phenylazoles |
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| Authors: | PS Aparna B Prabha Praveen Prakash E Jijy R Luxmi Varma KV Radhakrishnan |
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| Institution: | 1. Organic Chemistry Section, Chemical Sciences and Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR), Trivandrum 695019, India;2. Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India |
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| Abstract: | The first ruthenium catalyzed redox-neutral C–H activation strategy for the ring-opening of diazabicyclic olefins via C–H bond cleavage of phenyl azoles is reported. The developed method offers a novel route to functionalized cyclopentenes by employing less-expensive ruthenium catalyst and readily accessible biologically significant heteroarenes. The present protocol is a merger of the C–H activation of phenyl substituted heteroaromatics and subsequent β-nitrogen elimination of diazabicyclic olefins. |
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| Keywords: | Ruthenium Cyclopentene Bicyclic olefin C&ndash H activation Pyrazole |
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