Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation |
| |
Authors: | Jian-Jun Tang Li Zhang Li-Ping Jiang Lei Di Yong-Ming Yan Zheng-Chao Tu Cui-Ping Yang Zhi-Li Zuo Bo Hou Hou-Lin Xia Yong-Bin Chen Yong-Xian Cheng |
| |
Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People''s Republic of China;2. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, People''s Republic of China;3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People''s Republic of China;4. Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, People''s Republic of China;5. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, People''s Republic of China;6. Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100039, People''s Republic of China |
| |
Abstract: | Polyrhachis dives is consumed as an insect food in some regions of China. In this study, new dopamine derivatives, (+)-polyrhadopamine A (1a) and (−)-polyrhadopamine A (1b), (+)-polyrhadopamine B (2a) and (−)-polyrhadopamine B (2b), and polyrhadopamines C–E (3–5), were isolated from this species. The structures and stereochemistry of these substances were assigned by using spectroscopic and computational methods. Compounds 1a, 1b, 2a, and 2b are dimeric N-acetyldopamine derivatives, 3 is a dopamine analog containing an unusual sulfone group, and 4 and 5 possess a rare benzod]thiazole moiety. The functions of these substances as ROCK1/2 inhibitors, neural stem cell (NSCs) proliferation stimulators, immunosuppressive, and anti-inflammatory agents were determined. |
| |
Keywords: | Polyrhachis dives Dopamine derivative ROCK1/2 inhibitors NSCs |
本文献已被 ScienceDirect 等数据库收录! |
|