|
|||||
|
|
Efficient synthesis of trypsin inhibitor SFTI-1 via intramolecular ligation of peptide hydrazide |
|
| Authors: | Yi-Qun Chen Chen-Chen Chen Yao He Mu Yu Lin Xu Chang-lin Tian Qing-Xiang Guo Jing Shi Min Zhang Yi-Ming Li |
| Affiliation: | 1. School of Life Science, Anhui University, Hefei, Anhui 230601, China;2. School of Medical Engineering, School of Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China;3. China High Magnetic Field Laboratory, Chinese Academy of Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China;4. Department of Chemistry, University of Science and Technology of China, Hefei 230026, China |
| Abstract: | Cyclic peptide trypsin inhibitor SFTI-1 was synthesized via intramolecular ligation of a linear peptide hydrazide with high yield. This cyclization strategy did not cause epimerization at the C-terminal Arg residue. CD spectrum and NMR spectroscopy analysis demonstrated that well-folded SFTI-1 could be obtained via standard oxidative folding process. Thus, we present a simple and cost-efficient strategy for the synthesis of SFTI-1. |
| Keywords: | Cyclic peptides Protein chemical synthesis boldFont" >SFTI-1 Peptide hydrazides |
| 本文献已被 ScienceDirect 等数据库收录！ | |