Stereoselective total synthesis of (+)-boronolide, (+)-anamarine, 8-epi-spicegerolide |
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| Authors: | BV Subba Reddy V Veerabhadra ReddyK Praneeth |
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| Institution: | Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A stereoselective total synthesis of the naturally occurring cytotoxic lactones (+)-boronolide, (+)-anamarine, and 8-epi-spicigerolide is described. d-Xylose has been used as a chiral source to construct the four contiguous oxygenated stereogenic centers of target molecules. The diastereoselective allylation was performed using Brown’s protocol and the lactone moiety was prepared by ring closing metathesis. |
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| Keywords: | α β-Unsaturated lactones Natural products d-Xylose Brown&rsquo s allylation Ring-closing metathesis |
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