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Synthesis of the 6-6-6 tricyclic skeleton of the anti-influenza A diterpene wickerol A |
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| Authors: | Danson Kwong Jia Ye Jean-Alexandre Richard |
| Institution: | Organic Chemistry, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667, Singapore |
| Abstract: | A five-step synthesis of the 6-6-6 tricyclic skeleton of the diterpene wickerol A is described. The synthesis features a diastereoselective d-proline-mediated Robinson annulation and N-heterocyclic carbene-catalyzed Stetter reaction as key transformations to give the tricyclic carbon skeleton of this promising anti-influenza A natural product. |
| Keywords: | Natural products Diterpene Wickerol A Antivirals Influenza A |
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