Synthesis of phosphorylated isoindolinone derivatives |
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| Authors: | Andrzej Jó źwiak,Piotr M. Zagó rski,Mieczysław W. Płotka,Dariusz Cal |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland;2. Department of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland |
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| Abstract: | The synthesis of diethyl [2-(2-alkyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)ethyl]phosphonates and diethyl [3-(2-alkyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propyl]phosphonates, via metallation (sec-BuLi) of N-substituted isoindolin-1-ones and then the reaction of the generated lithiated species 4 with diethyl vinylphosphonate or diethyl 3-bromopropylphosphonate, respectively, is described. |
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| Keywords: | Heterocycles Lithiation Phosphorylation Michael addition Esters |
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