ZnCl2 catalyzed efficient synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole |
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Authors: | MdA Rahman Mohammad R Karim Md Arifuzzaman Tasneem A Siddiquee Aminul H Mirza |
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Institution: | 1. Department of Chemistry, Tennessee State University, 3500 John Merritt Blvd., Nashville, TN 37209, United States;2. Department of Chemistry, Iowa State University, Ames, IA 50011, United States;3. Faculty of Science, Universiti of Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam |
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Abstract: | New methods for the synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole have been described. No cyclizations took place in the absence of ZnCl2. 1,3,4-Thiadiazoles are formed in the presence of ZnCl2 alone, whereas oxadiazoles are produced when a base such as Et3N or KOH was used along with ZnCl2. % Yields are optimized. |
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Keywords: | Phenanthroline 1 3 4-Oxadiazole 1 3 4-Thiadiazole |
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