Solid-phase synthesis of polyfunctional polylysine dendrons using aldehyde linkers |
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Authors: | Daniel K Svenssen Sahar Mirsharghi Ulrik Boas |
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Institution: | 1. Innate Immunology Group, National Veterinary Institute, The Technical University of Denmark, Bülowsvej 27, DK-1870 Frederiksberg, Denmark;2. Center for Nanomedicine and Theranostics, The Technical University of Denmark, Building 345E, Ørsteds Plads, DK-2800 Kongens Lyngby, Denmark |
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Abstract: | A straightforward method for the solid-phase synthesis of C-terminally modified polylysine dendrons has been developed by applying bisalkoxybenzaldehyde and trisalkoxybenzaldehyde linkers. The method has been used for the synthesis of polylysine dendrons with a variety of C-terminal ‘tail groups’ such as alkyl, propargyl, and dansyl to give dendrons in high crude purity. Furthermore, the method was successful for the synthesis of dendrons with multiple N-terminal pentapeptide groups together with C-terminal alkyl and propargyl tail groups. Finally, the method was shown to be well-suited for automated synthesis. |
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Keywords: | Polylysine dendron Solid-phase synthesis Backbone amide linker Polyfunctional |
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