Toward the total synthesis of a lagunamide B analogue |
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Authors: | Sudip Pal Tushar Kanti Chakraborty |
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Institution: | 1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10 Jankipuram Extension, Sitapur Road, Lucknow 226031, India;2. Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India |
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Abstract: | Lagunamides, isolated from a marine cyanobacterium Lyngbya majuscule found in Singapore, showed very potent activities against Plasmodium falciparum and murine leukemia cell line (P388). Herein, a concise synthetic approach toward the total synthesis of a lagunamide B analogue is discussed. Macrolactonization, HWE-olefination, and modified Crimmin’s aldol are some of the key reactions featured in this synthesis. |
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Keywords: | Macrolactonization Macrolactamization Horner&ndash Wadsworth&ndash Emmons olefination Crimmin&rsquo s aldol 2-Methyl-6-nitrobenzoic anhydride (MNBA) |
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