An efficient and simple ligand from phthalandione for palladium-catalyzed Suzuki reaction in aqueous media |
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| Authors: | Haiyang Liu Hailong Liu Ruixiang Li Hua Chen |
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| Affiliation: | 1. Key Lab of Green Chemistry and Technology, Ministry of Education, The Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China;2. Advanced Materials Institute, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China |
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| Abstract: | An efficient and simple ligand derived from phthalandione was used for palladium catalyzed Suzuki coupling reaction in water/ethanol (V/V = 2/1) under aerobic conditions. The reaction exhibited a high catalytic efficiency even with lower Pd loading (0.002 mol %). In this work, the catalyst could be successfully used in coupling reaction between various aryl halides with phenylboronic acid in excellent yields with high turnover number (TON) (the maximal TON was up to 49,000 for the reaction of bromobenzene with phenylboronic acid). Moreover, this new ligand had been elucidated by 1H NMR, 13C NMR and X-ray crystal diffraction. |
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| Keywords: | Suzuki&ndash Miyaura reaction Palladium catalyst Aryl bromides Phthalandione |
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