Synthesis of 1-haloethenamides from ynamide through halotrimethylsilane-mediated hydrohalogenation |
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| Authors: | Kazuhiro Ohashi Shigenori MiharaAkihiro H Sato Masataka IdeTetsuo Iwasawa |
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| Institution: | Department of Materials Chemistry, Faculty of Science and Technology, Ryukoku University, Otsu, Shiga 520-2153, Japan |
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| Abstract: | A convenient synthesis of 1-haloethenamides has been achieved by utilizing halotrimethylsilane (TMSX, X = Cl, Br, I) and water. Halotrimethylsilane in 1 M CH2Cl2 solution functions as a halogen source of the in situ generated HX, and the HX added to the terminal triple bonds of ynamides in Markovnikov fashion. |
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| Keywords: | 1-Haloethenamide exo-Methylene Vinyl halide Hydrohalogenation |
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