The stereoselective total synthesis of PF1163A |
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Authors: | Harish Kumar A. Srinivas ReddyB.V. Subba Reddy |
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Affiliation: | Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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Abstract: | A stereoselective total synthesis of 13-membered macrocycle PF1163A, an antifungal agent, has been accomplished for the first time starting from d-xylose. This approach involves a diastereoselective allylation of lactal ether,3a reductive ring opening of tetrahydrofuran ring,3b asymmetric methylation reaction, Yamaguchi esterification, and ring closing metathesis as key steps. |
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Keywords: | Antifungal agent Evans methylation Yamaguchi esterification Ring closing metathesis |
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