Structure and absolute configuration of penicilliumine,a new alkaloid from Penicillium commune 366606 |
| |
| Authors: | Jiang-Bo He Yan-Nan Ji Dong-Bao Hu Shen Zhang Hui Yan Xin-Chun Liu Huai-Rong Luo Hua-Jie Zhu |
| |
| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academic of Sciences (CAS), Kunming 650204, PR China;2. Chinese Center for Chirality, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, and College of Pharmacy Sciences, Hebei University, Baoding 071002, PR China;3. Graduate University of CAS, Beijing 100049, PR China. |
| |
| Abstract: | Penicilliumine (1), a new structure was isolated from the fermentation Penicillium commune 366606, a marine-derived fungus isolated from the sea water collected at Qingdao, China. HPLC chiral separation of 1 afforded two enantiomers (−)-penicilliumine and (+)-penicilliumine, respectively. The structure of 1 was established by comprehensive spectroscopic data, and single-crystal X-ray diffraction. The absolute configuration of enantiomers was determined by quantum mechanical computation of electronic circular dichroism (ECD). |
| |
| Keywords: | Penicillium commune Penicilliumine ECD Matrix Absolute configuration |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
