Pleosporin A,an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069) |
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Authors: | Masahiko Isaka Somporn PalasarnSomjit Komwijit Sayanh SomrithipolSujinda Sommai |
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Affiliation: | National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand |
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Abstract: | Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6 μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50 μg/mL. |
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Keywords: | Coprophilous fungi Pleosporaceae SCH 217048 Cyclodepsipeptide Antimalarial activity |
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