| 多相酶膜反应器合成生物活性二肽 |
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| 引用本文： | 姜忠义,贾琦鹏,刘家祺,陈洪钫. 多相酶膜反应器合成生物活性二肽[J]. 应用化学, 2001, 18(1): 56-0 |
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| 作者姓名： | 姜忠义 贾琦鹏 刘家祺 陈洪钫 |
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| 作者单位： | 天津大学 |
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| 基金项目： | 国家自然科学基金资助课题（B29604） |
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| 摘 要： | 生物活性肽;多相酶膜反应器合成生物活性二肽
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| 关 键 词： | 生物活性肽 多相酶膜反应器合成生物活性二肽 |
| 文章编号： | 1000-0518(2001)01-0056-03 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2000-05-30 |
Synthesis of BiologicallyActive Dipeptide in a Multiphase Enzyme Membrane Reactor |
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| JIANG Zhong Yi ,JIA Qi Peng,LIU Jia Qi,CHEN Hong Fang [WTBX]. Synthesis of BiologicallyActive Dipeptide in a Multiphase Enzyme Membrane Reactor[J]. Chinese Journal of Applied Chemistry, 2001, 18(1): 56-0 |
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| Authors: | JIANG Zhong Yi JIA Qi Peng LIU Jia Qi CHEN Hong Fang [WTBX] |
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| Affiliation: | JIANG Zhong Yi *,JIA Qi Peng,LIU Jia Qi,CHEN Hong Fang [WT5BX] |
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| Abstract: | A multiphase enzyme membrane reactor using aqueous organic biphase instead of water phase alone as the reaction medium was employed to investigate the lipase catalyzed synthesis of bioactive dipeptides. The medium effect on dipeptide yield was first studied. When N acetyl L phenylalanine ethyl ester(APEE) was used as a carboxyl component, the reactivity order of amino acid amides was found to be L Leu NH 2> L Val NH 2> L Ala NH 2> L Gly NH 2. The didpetide, N Ac L Phe L Leu NH 2, could be synthesized in the multiphase enzyme membrane reactor in a high yield and purity due to the simultaneous separation and reaction. |
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| Keywords: | lipase multiphase membrane reactor synthesis biologically active dipeptide |
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