Rapid aqueous ‘click chemistry’ using Cu(I)-loaded dendrimers as macromolecular catalysts |
| |
Authors: | Eli MooreSteven J. McInnes Andrew VogtNicolas H. Voelcker |
| |
Affiliation: | Flinders University, School of Chemical and Physical Sciences, Sturt Road, Bedford Park, Adelaide, SA 5042, Australia |
| |
Abstract: | Here, we investigate the catalytic activity of various copper (Cu)-loaded poly(amido amine) (PAMAM) dendrimers towards the Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC). Reactivity is tested on a model reaction between azido propanol and propargyl alcohol in aqueous solution. We observe significantly faster conversion using PAMAM dendrimers as macromolecular Cu(I) ligands compared to traditional small molecular ligand systems, and demonstrate that the macromolecular catalyst can be removed by ultrafiltration. |
| |
Keywords: | Click chemistry PAMAM Dendrimer Catalyst |
本文献已被 ScienceDirect 等数据库收录! |