Simple protocol for enhanced (E)-selectivity in Julia-Kocienski reaction |
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| Authors: | Ji?í Pospí &scaron il |
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| Affiliation: | Institute of Condensed Matter and Nanosciences—Molecules, Solids and Reactivity (IMCN/MOST), Université catholique de Louvain, Place Louis Pasteur, 1 bte 2, 1348 Louvain-la-Neuve, Belgium |
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| Abstract: | A short and efficient Julia-Kocienski olefination protocol, based upon the use of chelating agents (18-crown-6 or TDA-1 for K+; 12-crown-4 or HMPA for Li+), was developed. This protocol enhances the (E)-selectivity of the reaction and the desired olefins are obtained generally with >10:1 (E/Z)-selectivity. |
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| Keywords: | Julia-Kocienski reaction Olefins Selectivity Chelation |
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