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Synthesis of new 1H-1,2,4-triazolylcoumarins and their antitumor and anti-HIV activities |
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| Authors: | Y A Al-Soud I A Al-Masoudi B Saeed U Beifuß N A Al-Masoudi |
| Institution: | 1. Department of Chemistry, College of Science, University of Al al-Bayt, Al-Mafraq, Jordan 2. College of Veterinary, University of Basrah, Basrah, Iraq 3. Department of Chemistry, College of Education, University of Basrah, Basrah, Iraq 4. Fakult?t für Chemie, Universit?t Hohenheim, Germany 5. Formerly Fachbereich Chemie, Universit?t Konstanz, Germany |
| Abstract: | A variety of 7-(1,5-dialkyl-1H-1,2,4-triazolyl)methoxy(and methyl)]coumarins were synthesized from cycloaddition of 2-(2H-benzopyran-7-yloxy)acetonitrile
and 2-(5-methoxy-4-methyl-2H-benzopyran-7-yloxy)acetonitrile, respectively, with various reactive cumulene
intermediates via spontaneous rearrangements. The anticancer (breast, lung, CNS cancers) and antiviral (HIV-1, HIV-2) properties
of some compounds were investigated in vitro. 5-Methoxy-4-methyl-7-(6,7,8,9-tetrahydro-5H-1,2,4]triazolo1,5-a]azepin-2-yl)methyl]coumarin
showed some inhibition of HIV-1.
Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 669–678, May, 2006. |
| Keywords: | antitumor activity antiviral activity coumarin 1 2 4-triazoles cycloaddition |
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