Approaches to oximidines, lobatamides and related natural products: the coupling reactions of 3-iodoacrolein O-methyl oximes |
| |
Authors: | Steven A Raw Richard J K Taylor |
| |
Institution: | Department of Chemistry, University of York, Heslington, York YO10 5DD, UK |
| |
Abstract: | Both 2E- and 2Z-3-iodoacrolein O-methyl oximes are prepared in two steps from ethyl propiolate. Lithium–iodine exchange is effected and the resulting organolithium reagents added to several electrophiles, including styryl isocyanate which gives a conjugated O-methyl oxime enamide of the type found in the side chains of the oximidine, lobatamide and CJ-12950 natural products. The Pd(0) catalysed cross-coupling of these iodoalkenes is also explored. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|