Novel Peptide Chemistry in Terrestrial Animals: Natural Luciferin Analogues from the Bioluminescent Earthworm Fridericia heliota |
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| Authors: | Maxim A Dubinnyi Aleksandra S Tsarkova Valentin N Petushkov Zinaida M Kaskova Natalja S Rodionova Sergey I Kovalchuk Rustam H Ziganshin Mikhail S Baranov Konstantin S Mineev Ilia V Yampolsky |
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| Institution: | 1. Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho‐Maklaya 16/10, Moscow 117997 (Russia);2. Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia);3. Laboratory of Photobiology, Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia) |
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| Abstract: | We report isolation and structure elucidation of AsLn5, AsLn7, AsLn11 and AsLn12: novel luciferin analogs from the bioluminescent earthworm Fridericia heliota. They were found to be highly unusual modified peptides, comprising either of the two tyrosine‐derived chromophores, CompX or CompY and a set of amino acids, including threonine, gamma‐aminobutyric acid, homoarginine, and unsymmetrical N,N‐dimethylarginine. These natural compounds represent a unique peptide chemistry found in terrestrial animals and rise novel questions concerning their biosynthetic origin. |
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| Keywords: | bioluminescence Fridericia heliota luciferin peptides structure elucidation |
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