Copper‐Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols |
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| Authors: | Jian Lei Xiaowu Liu Shaolin Zhang Shuang Jiang Minhao Huang Prof. Dr. Xiaoxing Wu Prof. Dr. Qiang Zhu |
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| Affiliation: | Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530 (P. R. China) |
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| Abstract: | An efficient copper‐catalyzed trifluoromethylation of trisubstituted allylic and homoallylic alcohols with Togni’s reagent has been developed. This strategy, accompanied by a double‐bond migration, leads to various branched CF3‐substituted alcohols by using readily available trisubstituted cyclic/acyclic alcohols as substrates. Moreover, for alcohols in which β‐H elimination is prohibited, CF3‐containing oxetanes are isolated as the sole product. |
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| Keywords: | (homo)allylic alcohols branched products copper radical reactions trifluoromethylation |
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