Regio‐ and Chemoselective N‐1 Acylation of Indoles: Pd‐Catalyzed Domino Cyclization to Afford 1,2‐Fused Tricyclic Indole Scaffolds |
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| Authors: | Yongxian Liu Yuanqiong Huang Hongjian Song Yuxiu Liu Prof Qingmin Wang |
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| Institution: | State Key Laboratory of Elemento‐Organic Chemistry, Research Institute of Elemento‐Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China), Fax: (+86)?22‐23503952 |
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| Abstract: | A concise method for the synthesis of 1,2‐fused tricyclic indole scaffolds by domino cyclization involving a Pd‐catalyzed Sonogashira coupling, indole cyclization, regio‐ and chemoselective N‐1 acylation, and 1,4‐Michael addition is reported. This method provides straightforward access to tetrahydro1,4]diazepino1,2‐a]indole and hexahydro1,5]diazocino1,2‐a]indole scaffolds. |
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| Keywords: | chemoselectivity cyclization domino reactions indoles palladium regioselectivity |
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