One‐Pot Synthesis of O‐Allylhydroxylamines through the Organocatalytic Oxidation of Tertiary Allylic Amines Followed by a [2,3]‐Meisenheimer Rearrangement |
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| Authors: | Alexis Theodorou Dr. Dimitris Limnios Prof. Dr. Christoforos G. Kokotos |
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| Affiliation: | Laboratory of Organic of Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens (Greece) |
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| Abstract: | A cheap, green, and highly efficient one‐pot method for the synthesis of O‐protected allylic alcohols is described. By utilizing 2,2,2‐trifluoroacetophenone as the organocatalyst and H2O2 as the oxidant, a variety of allylic amine N‐oxides were synthesized, which upon heating are converted to the final products through a [2,3]‐Meisenheimer rearrangement. |
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| Keywords: | alcohols green chemistry organocatalysis oxidation rearrangement |
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