Formal [4+2] Reaction between 1,3‐Diynes and Pyrroles: Gold(I)‐Catalyzed Indole Synthesis by Double Hydroarylation |
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| Authors: | Yuka Matsuda Saori Naoe Dr Shinya Oishi Prof?Dr Nobutaka Fujii Prof?Dr Hiroaki Ohno |
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| Institution: | Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo‐ku, Kyoto 606‐8501 (Japan) |
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| Abstract: | Indole synthesis by a gold(I)‐catalyzed intermolecular formal 4+2] reaction between 1,3‐diynes and pyrroles has been developed. This reaction involves the hydroarylation of 1,3‐diynes with pyrroles followed by an intramolecular hydroarylation to give the 4,7‐disubstituted indoles. This reaction can also be applied to the synthesis of carbazoles when indoles are used as the nucleophiles instead of pyrroles. |
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| Keywords: | carbazoles cascade reaction gold catalysis hydroarylation indoles |
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