New substances against human immunodeficiency virus: sulfated 5'-nucleotidase inhibitory polyphenols. |
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| Authors: | T Toukairin K Uchino T Mizuno H Nakashima N Yamamoto H Ogawara |
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| Affiliation: | Central Laboratory, Nippon Flour Mills Co., Ltd., Kanagawa, Japan. |
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| Abstract: | Two sulfated polyphenols, NF-86II-S-13.3 and NF-86II-S-6.2, were synthesized from NF-86II without sulfur their inhibitory effect on human immunodeficiency virus (HIV) infection in vitro was examined, using cytopathic effect and an antigen expression assay system in MT-4 cells. NF-86II-S-13.3 (sulfur content, 13.3%) completely inhibited the cytopathic effect of HIV and the HIV-specific antigen expression in MT-4 cells at concentrations of more than 6.3 micrograms/ml. The effect of NF-86II-S-6.2 (sulfur content, 6.2%) was much weaker than that of NF-86IIS-13.3. On the other hand, NF-86II without sulfur did not show any activity at all. |
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