Synthesis and Acidity of 5-Phenyltetrazol-2-ylalkanoic Acids and the Corresponding 5-(5-Phenyltetrazol-2-ylalkyl)tetrazoles |
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Authors: | K. A. Esikov V. Yu. Zubarev E. V. Bezklubnaya A. A. Malin V. A. Ostrovskii |
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Affiliation: | (1) St. Petersburg State Technological Institute (Technical University), St. Petersburg, 198013, Russia |
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Abstract: | We have obtained 5-phenyltetrazol-2-ylalkanoic acids and their derivatives containing terminal nitrile, amide, and tetrazol-5-yl groups. Tetrazolylalkanoic acids with two (pKa 4.93) and three (pKa 5.45) bridging methylene groups are weaker acids than the corresponding ditetrazoles pKa 4.68 and 5.29 respectively). However, the acidity of 5-phenyltetrazol-2-ylacetic acid (pKa 3.12), is higher than acidity of the corresponding ditetrazole (pKa 3.27). |
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Keywords: | ditetrazoles tetrazoles tetrazolylalkanoic acids acidity |
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