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Stereoselective synthesis of (+)-radicamine B |
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| Authors: | G ShankaraiahR Sateesh Chandra Kumar B PoornimaK Suresh Babu |
| Institution: | Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India |
| Abstract: | A simple and efficient stereoselective synthesis of naturally occurring pyrrolidine alkaloid, radicamine B has been accomplished in 13 steps from the commercially available starting materials with an overall yield of 9.75%. The synthesis utilizes Sharpless asymmetric epoxidation and Horner-Wadsworth-Emmons (HWE) olefination as key steps. |
| Keywords: | Pyrrolidine alkaloids Radicamines Sharpless asymmetric epoxidation HWE olefination |
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