Mass Spectrometry Profiling of the Protein Composition of Blood Plasma of Colorectal Cancer Patients |
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| Authors: | A. L. Kaysheva A. T. Kopylov T. O. Pleshakova N. E. Kushlinskii V. G. Nikitaev E. A. Druzhinina A. I. Archakov Yu. D. Ivanov |
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| Affiliation: | 1.Institute of Biomedical Chemistry,Moscow,Russia;2.N. N. Blokhin National Medical Research Centre of Oncology,Moscow,Russia;3.National Research Nuclear University “MEPhI”,Moscow,Russia |
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| Abstract: | The objective of the study is themass spectrometry analysis of the protein composition in blood plasma samples of large intestine cancer patients. Protein profiles of 58 blood plasma samples of large intestine cancer patients and healthy volunteers are analyzed using ultrahigh-resolution panoramic mass spectrometry. It is shown that the coincidence of identifications in the protein composition samples of intestine cancer patients and healthy men is 60–80%. Samples of intestines cancer patients contain proteins involved in the interaction with ribonucleic acid, proteins, and lowmolecular substrata. |
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