| 一类新的嘌呤核苷类似物的合成及简单生物活性检测 |
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| 引用本文： | 李达谅,鲍红丽,谭启涛,柯玉萍,尤田耙. 一类新的嘌呤核苷类似物的合成及简单生物活性检测[J]. 中国化学, 2005, 23(12): 1659-1664. DOI: 10.1002/cjoc.200591659 |
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| 作者姓名： | 李达谅 鲍红丽 谭启涛 柯玉萍 尤田耙 |
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| 作者单位： | Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （No. 20172049）. |
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| 摘 要： | Convenient procedure for coupling of 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and 4-nitroimidazole was provided to obtain β-anomer as major product. A novel category of nucleoside analogues with an imidazole base moiety bearing amino-acid residue was designed and synthesized to develop selective and effective antiviral agents. They were evaluated for the anti-HBV activity.
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| 关 键 词： | 嘌呤 核苷 病原体 三唑 氨基酸 苷化 合成方法 生物评价 |
| 收稿时间： | 2005-03-21 |
| 修稿时间： | 2005-03-212005-08-30 |
Synthesis and Biological Evaluation of a New Category of Purine-Nucleoside Analogues |
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| LI Da-Liang, BAO Hong-Li, TAN Qi-Tao, KE Yu-Ping, YOU Tian-Pa. Synthesis and Biological Evaluation of a New Category of Purine-Nucleoside Analogues[J]. Chinese Journal of Chemistry, 2005, 23(12): 1659-1664. DOI: 10.1002/cjoc.200591659 |
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| Authors: | LI Da-Liang BAO Hong-Li TAN Qi-Tao KE Yu-Ping YOU Tian-Pa |
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| Affiliation: | Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China |
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| Abstract: | Convenient procedure for coupling of 1,2,3,5‐tetra‐O‐acetyl‐β‐D‐ribofuranose and 4‐nitroimidazole was provided to obtain β‐anomer as major product. A novel category of nucleoside analogues with an imidazole base moiety bearing amino‐acid residue was designed and synthesized to develop selective and effective antiviral agents. They were evaluated for the anti‐HBV activity. |
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| Keywords: | antiviral purine nucleoside ribavirin amino acid glycosidation |
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