Effect of mobile phase density gradients on efficiency in packed column supercritical fluid chromatography |
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Authors: | T A Berger J F Deye |
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Institution: | (1) Hewlett-Packard Company, P.O. Box 900, 19311-0900 Avondale, PA, USA |
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Abstract: | Summary The efficiency of packed columns was measured as a function of flow rate, temperature, outlet density, and the density differential across the column, unsing pure carbon dioxide as the mobile phase. Although density differentials are often blamed for a serious loss in efficiency in packed column supercritical fluid chromatography, the results show that efficiency was not a function of the density differential. Peak shapes suggest that apparent loss in efficiency is actually due to inadequate solubility of the solute in carbon dioxide. |
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Keywords: | Supercritical fluid chromatography (SFC) Packed columns Density gradients Effect on efficiency |
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