| 取代芳甲酰哌嗪新衍生物的合成及其药理活性 |
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| 引用本文： | 徐鸣夏,杨艳.取代芳甲酰哌嗪新衍生物的合成及其药理活性[J].化学研究与应用,1999,11(5):523-524. |
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| 作者姓名： | 徐鸣夏 杨艳 |
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| 作者单位： | 华西医科大学药学院!成都６１００４１(徐鸣夏，周国川，李瑞雪)，沪州医学院!沪州６４６０００(杨艳，刘智飞，曾晓荣)，四川大学!成都６１００６４(谢益农) |
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| 摘 要： | １引言充血性心力衰竭是目前临床上较为常见的心血管系统疾病之一，由其引起的死亡率在不断增加。维司力农（Ｖｅｓｎａｒｉｏｎｅ，ＯＰＣ－８２１２，Ｉ）作为正性肌力药于１９９０年首先在日本上市，其正性肌力作用选择性高，无明显变时效应和血管作用。但该化合物结构复杂，合成路线较长且安全范围较窄［’１。本课题组以维司力农为模型化合物，将其结构改造，得到一系列３，４一二甲氧基苯甲酸听唤衍生物，药理试验表明具一定的正性肌力作用出。在此基础上，作者设计以吹哺甲酸基及（取代）苯甲酸基代替３，４一二甲氧基苯甲酚基，合成…
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| 关 键 词： | 取代芳甲酰基哌嗪衍生物 正性肌力作用 合成 |
SYNTHESIS AND POSITIVE INOTROPIC ACTIVITY OF SUBSTITUTED AROYL PIPERAZINE DERIVATIVES |
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| Xu Ming-Xia, Zhou Guo-Chuan, Yang Yan, Xie Yi-Nong ,Liu Zhi-Fei, Zeng Xiao-Rong, Li Rui-Xue.SYNTHESIS AND POSITIVE INOTROPIC ACTIVITY OF SUBSTITUTED AROYL PIPERAZINE DERIVATIVES[J].Chemical Research and Application,1999,11(5):523-524. |
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| Authors: | Xu Ming-Xia Zhou Guo-Chuan Yang Yan Xie Yi-Nong Liu Zhi-Fei Zeng Xiao-Rong Li Rui-Xue |
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| Abstract: | We designed and synthesized 5 new compounds. Their chemical structures were confirmed by means of MS, HNMR andelemental analysis. FPA was tested for positive inotropic activity. The results showed that FPA could increase the contrastive amplitudeof isolated atrium of guinea pigs and had no influence upon rhythm of the hearts. |
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| Keywords: | substitoted aroyl piperazine derivatives positive inotropic activity synthesis |
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