Nucleotide,XVII. Synthese von homogenen Adenosyl-3′,5′-Oligomeren nach dem Phosphotriester-Verfahren |
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Authors: | Dieter Flockerzi Eugen Uhlmann Wolfgang Pfleiderer |
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Abstract: | Nucleotides, XVII. Synthesis of Homogeneous Adenosyl-3′,5′-oligomers by the Phosphotriester Method The chemical synthesis of the fully protected trimer 12 , the tetramers 11 and 23 as well as the pentamer 14 was achieved in preparative scales starting from the fully blocked adenosine-3′-phosphotriesters 1, 2 , and N6-benzoyl-2′,3′-bis-O-(tert-butyldimethylsilyl)adenosine (6) . All intermediates and end products have been isolated, purified and characterized by elemental analyses, UV, and CD spectra. Deprotection of the various blocking groups proceeds without difficulties to afford the free trimeric, tetrameric, and pentameric oligoadenylates 15, 16 , and 24 in high yields. |
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