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Synthesis of 4(5)-hydroxymethylimidazoles by hydroxymethylation and decarboxylation of imidazole-4(5)-carboxylic acids |
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| Authors: | Choong S Kim Kee J Lee Hong S Kim Yung B Chae |
| Abstract: | 4(5)-Hydroxymethylimidazoles were prepared by hydroxymethylation and decarboxylation of imidazole-4(5)-carboxylic acid esters. The reaction was simply carried out with aqueous formaldehyde solution in the presence of base. |
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